ABSTRACT
Zinc oxide nanoparticles play a vital role in diagnostics, biomolecular detection, and microelectronics. Several conventional methods are used for synthesis of zinc oxide nanoparticles. But, toxic chemicals are required as capping agents to maintain stability, thus leading to toxicity in the environment. Thus, we need to shift to “green synthesis”. Hence, this study was conducted to assess the cytotoxicity, antiinflammatory, and antioxidant activity of zinc oxide nanoparticles reinforced with clove and cinnamon.METHODSCytotoxic effect, anti-inflammatory activity, antioxidant activity of zinc oxide nanoparticles reinforced with clove and cinnamon extract were assessed using Brine Shrimp Assay, Bovine Serum Albumin (BSA) and DPPH Assay respectively at 5 µL, 10 µL, 20 µL, 30 µL, 50 µL.RESULTSAs the concentration increased, the cytotoxicity of the nanoparticles increased. Values for anti-inflammatory property of nanoparticles was higher than the standard values at all concentrations. Percentage of inhibition was highest at 40 µL (91.1%) and 50 µL (90.5%). The values for antioxidant property of nanoparticles was found to be higher than the standard values at all concentrations except at 50 µL. Percentage of inhibition was highest at 20 µL (86.2%).CONCLUSIONSZinc oxide nanoparticles reinforced with clove and cinnamon extract have a potential as an anti-cancer, anti-inflammatory and antioxidant agent and can be used as an alternative to commercially available products.